Developmental and Epileptic Encephalopathies are among the most challenging conditions faced by neurologists and neuropsychiatrists. Development is often hampered by neurologic disruption, which may include frequent seizures, thought processing difficulties and a range of cognitive challenges. Immune disorders and metabolic problems may also be present. Common syndromes such as Lennox Gastaut and Dravet’s syndromes will be addressed. Strategies to identify treatment targets will be discussed, especially as symptom presentations may vary in this population.