Huntington disease (HD) is an autosomal dominantly inherited neurodegenerative disorder characterized by motor, behavioral, and cognitive symptoms. Clinical presentation can vary in age of onset and symptom predominance. Many effective treatments exist for motor and emotional symptoms of HD. Concurrently, active research is unraveling additional information on genetics, pathophysiology, and additional potential therapeutic targets. This session will outline an overview of Huntington disease, with an emphasis on clinical presentation, important components of clinical care, current treatment options, and promising future therapeutics.